Abstract
In this study we observed activity paraoxonase1 (PON1), and serum amyloid A (SAA) and their role in the pathogenesis of breast cancer (BC) and the pancreas (PC). Paraoxonase1 calcium-dependent esterase is bound to HDL by apoA1 is capable of hydrolysing organophosphate insecticides and nerve gases.
It also exhibits activity lactonasis. An important role of PON1 in the body is to protect LDL lipid peroxidation and before hydrolysis of oxidized phospholipids.
At present, two were published works dealing with PON1 activity in patients with the PC and in both cases was observed in this disease decreased activity PON1. Also in patients with BC were observed reduced activity PON1.
The aim of this study was to determine the activity of PON1 in patients with breast cancer and pancreas compared to healthy controls, and then examining the relationship between the activity of PON1 and SAA concentrations.