Low-dose cholecalciferol supplementation and dual vitamin D therapy in haemodialysis patients

Abstract

Traditionally, secondary hyperparathyroidism (SHPT) due to low calcitriol synthesis in failing kidneys has been treated with synthetic vitamin D receptor (VDR) activators. Recently, also the importance of low native vitamin D status beyond the issue of SHPT has been recognized in these patients.

The aim of this work was to evaluate the effect of cholecalciferol supplementation in haemodialysis patients with low vitamin D serum levels. Another aim was to evaluate dual vitamin D therapy (cholecalciferol supplementation plus paricalcitol) in haemodialysis patients with vitamin D deficiency and concomitant SHPT.

Keywords

• Cholecalciferol
• Parathyroid hormone
• Vitamin D supplementation
• Paricalcitol
• Dual vitamin D therapy
• Haemodialysis