CT imaging and spontaneous behavior analysis after osmotic blood-brain barrier opening in Wistar rat
2014
Abstract
In our previous experiments we demonstrated that osmotic opening of the blood brain barrier (BBB) in rats by administration of mannitol into the internal carotid artery leads to cerebral oedema. The aim of this study was to confirm objectively the development of brain oedema and determine whether it affects spontaneous locomotor activity in rats (SLA).
Brain oedema was verified by computed tomography (CT) examination of the brain and SLA was observed during open field test.