Genetic Analysis of the Cardiac Methylome at Single Nucleotide Resolution in a Model of Human Cardiovascular Disease

Abstrakt

Epigenetic marks such as cytosine methylation are important determinants of cellular and whole-body phenotypes. However, the extent of, and reasons for inter-individual differences in cytosine methylation, and their association with phenotypic variation are poorly characterised.

Here we present the first genome-wide study of cytosine methylation at single-nucleotide resolution in an animal model of human disease.

Klíčová slova

• Genetic
• Analysis
• Cardiac
• Methylome
• Single
• Nucleotide
• Resolution
• Model
• Human
• Cardiovascular
• Disease