Abstract
Synchronous high frequency (Gamma band) activity has been proposed as a candidate mechanism for the integration or 'binding' of distributed brain activities that are closely related to integrative cognitive processing and conscious awareness which is significantly affected in schizophrenia. According to recent evidence schizophrenia is related to temporal disintegration of brain networks which is closely linked to cognitive dysmetria to abnormal integration of sensory input with stored information.
These findings indicate that disconnection and disturbed gamma synchrony and neural binding may represent a specific correlate of mental disintegration in schizophrenia. From historical perspectives these findings are in agreement with basic thinking about schizophrenia that was proposed by Bleuler when he introduced the term schizophrenia as "split mind".
These data have important implications for understanding of basic mechanism related to schizophrenia and also its therapy that in the future perspectives might be much focused on specific influences on cognitive functions using psychotherapeutic approaches in close correspondence with pharmacological treatment strategies.