Statistical evaluation of cytokine production in relation to mononucleotide polymorphisms in patients with chronic periodontitis
Abstrakt
Aim: The aim of this poster is to demonstrate the possibilities of the multiple application of non-parametric statistical methods, regarding the formal analysis of cytokine production in relation to polymorphisms of genes "candidate" for acute and chronic periodontitis and presentation of the results. Results: We have found the specific significant correlations of cytokine productions in groups of parodontitics towards controls.
The key role inside Factor1 (FA1 with 16.8% of explaned variability between polymorphisms) plays IL10-1084 polymorphism on allele GG, which increases levels of cytokine IFN-γ, IL-17 and IL-5, non-stimulated and stimulated values for all bacteria (Tf, Tg, Aa and Pi). The candidate polymorphisms around IL-18 (FA2: 14.0%) also expressed bacteria Tf and Pi on IL-10, IL-5, VEGF etc., but probably not specifically only for group with parodontitis.
Not only patients with parodotosis with ApoE 23 or persons from control group, which are predispose by polymorphism IL-6-174, will produce more cytokine IL-17 or IL-5 after expression of bacteria Pg and Pi (FA3 with 12.0%). Due mapping of all significances presented on Fig. 3 or Fig.4 we can show that is not possible to expect the same effect of increasing levels of cytokine to be uniform from all "genetic candidates" from families of IL-10 or IL-6, for example.