Hyperparathyroidism detection using 99mTc-MIBI SPECT/low dose CT and 3D subtraction methods of 99mTc-MIBI SPECT - 99mTcO4 SPECT in patients with osteoporosis
Abstract
AIM: Prove the utility of 18F-fluorocholine (FCH) PET/CT examination in the localisation of hyper productive parathyroid tissue. METHOD: 15 patients with negative or equivocal findings in 99mTc-MIBI scan and clear evidence of hyperparathyroidism (high level of calcium and parathyroid hormone - PTH) were examined with FCH PET/CT.
PET scan was obtained 10 - 20 minutes after intravenous injection of 100 MBq FCH. Extent of scanning was from scull base to diaphragm.
Time for bed was prolonged to 7 minutes for thyroid region and 5 minutes for the rest of chest. CT was performed in standard conditions with Iomeron as contrast agent.FCH PET/CT examination seems to be very promising tool for localisation of hyper productive parathyroid tissue even in cases when classical MIBI scan is negative.
Contrast of lesions probably depends from severity of hyperparathyroidism.