Omega-3 polyunsaturated fatty acids affect arrhythmogenic factors and attenuate susceptibility of the heart to malignant arrhythmias in an experimental model of human essential hypertension
2014
Abstrakt
Omega-3 polyunsaturated fatty acids intake significantly reduced cardiovascular risk factors, suppressed incidence of ventricular fibrillation and facilitated sinus rhythm restoration in SHR at early and late stage of hypertension. The antiarrhythmic effects of omega-3 can be attributed to attenuation of abnormal myocardial Cx43 distribution, expression and phosphorylation as well as to positive modulation of PKC-epsilon and PKC-delta signaling and normalization of MyHC profiles.
Findings support prophylactic use of omega-3 to minimize a risk for lethal arrhythmias in hypertensive individuals