Influence of high temperature on the formation of degradation products of vancomycin released from local carriers used in orthopedics
Abstract
Local application of antibiotics with the help of local carriers used in orthopedics is a proven method of treatment of infections of the locomotor system. Vancomycin is increasingly being used for local therapy in orthopedics due to the increase in methicillin resistant bacteria.
However, vancomycin subject to thermal degradation to produce crystalline antibacterially inactive degradation products (CDP-1). Previous experiments we verified that the active form (factor B) and CDP-1s emitted from polymethyl at much lower levels than that of bone grafts.
Based on results of recent experiments, we found that the active form of vancomycin and CDP-1s were released from the bone graft at 80 o C, almost the same levels as a bone graft with vancomycin at 37 o C. So we have not confirmed the effect of higher temperatures on greater production CDP-1s.
The reason for the lower levels of vancomycin released from bone cement is due to the fact that most antibiotics are integrated inside the material.