An efficient oxa-Michael addition to diethyl vinylphosphonate under mild reaction conditions

Abstract

An oxa-Michael addition of various secondary and branched primary alcohols to diethyl vinylphosphonate was systematically studied and optimized. This efficient method precedes using of harsh reaction conditions (e.g. strong bases, high temperatures) and gains access to an important class of biologically active compounds in one step.

Keywords

• oxa-Michael addition
• diethyl vinylphosphonate
• mild reaction conditions