Unique BHLHB3 overexpression in pediatric acute myeloid leukemia with t(6;11)(q27;q23)

Abstract

Within pediatric MLL-rearranged acute myeloid leukemia (AML), the translocation partners have been shown to be clinically highly relevant.1 The most striking example is the t(6;11)(q27;q23) subtype, which has an event-free survival of only 11% and estimated overall survival of only 22%. This poor outcome is determined by a high induction-failure rate (26%), as well as a high-relapse rate (57%).

Keywords

• transcription factor dec2
• breast-cancer cells
• loop
• expression
• target
• gene