Abstract
Oncologic results of radical prostatectomy in men with high-risk clinically localised and locally advanced prostate carcinoma can be both good and bad. Men with a clinically localised carcinoma and markers of high risk of progression, like Gleason score of 8-10 or PSA > 20 mg/ml can be treated by radical prostatectomy alone.
On the other hand, men after radical prostatectomy for a high risk carcinoma require adjuvant treatment for locoregional spread of the disease. The surgery is thus a part of a multi-modal therapy.
The results can depend on the specific parameters of the disease in the individual patient. This overview article deals with indications for radical prostatectomy in patients with a post-operational risk of disease progression and parameters influencing the extra-prostatic presence of the tumour.