Effects of captopril, spironolactone, and simvastatin on the cardiovascular system of non-diseased Wistar rats

Abstract

There is an obvious uncertainty concerning the effect of cardiovascular drugs with pleiotropic actions during long-term treatment of "healthy"-non-diseased individuals. To the best of our knowledge, we have shown for the first time in the prospective animal study that a long-term treatment with captopril, spironolactone or simvastatin of non-diseased rats did not lead to any undesirable structural changes of the LV or kidney and it even improved endothelial function.

Keywords

• Captopril
• spironolactone
• simvastatin
• fibrosis
• endothelial function
• protection
• non-diseased heart
• protein remodeling