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The Contribution of Proteinase-Activated Receptors to Intracellular Signaling, Transcellular Transport and Autophagy in Alzheimer's Disease

Publication at First Faculty of Medicine, Third Faculty of Medicine |
2015

Abstract

The etiopathogenesis of Alzheimer's disease is characterized by beta amyloid A beta((1-42)) toxic fragment aggregation and its association with impaired autophagy. In mitochondria, chronic damage due to transport and enzymatic processes together with the production of reactive oxygen species (ROS) are followed by the subsequent accumulation of A beta in the form of senile plaques and the accumulation of hyperphosphorylated tau protein in intracellular deposits called tangles.

Proteinase-activated receptors (PARs), members of the G protein-coupled receptor (GPCR) family, facilitate and modulate the transcellular transport and distribution of a variety of subcellular molecular components to the lysosomal system and, thus, influence their degradation. A review of the data shows that the activation or inhibition of PARs leads to changes in the process of autophagy, which may influence ROS production and A beta((1-42)) degradation in lysosomes and result in AD pathogenesis.