Monoclonal Antibody Against Transforming Growth Factor Beta 1 Does Not Influence Liver Regeneration After Resection in Large Animal Experiments
Abstract
In our study, we did not find any effect of MAB-TGFβ on liver regeneration following toxic injury, although we had hypothesized that there would be an effect on the basis of our previous study. The cause of this discrepancy could be extensive toxic injury induced without pauses between the toxic insults, similarly to that which would occur in patiens undergoing chemotherapy treatments.
However, it remains unclear whether CASH and liver fibrosis are reversible, or if it is possible to alleviate these conditions. Our usage of the MAB-TGFβ treatment did not show that this is possible.
We demonstrated that systemic early preoperative administration of MAB-TGFβ does not significantly influence liver regeneration in a porcine experimental model of liver resection. The data presented herein support the organisation of future studies to examine the effects of neoadjuvant biological therapy on liver malignancy in human medicine.