Publication at Faculty of Medicine in Pilsen, Faculty of Medicine in Hradec Králové |
2015
Abstract
MicroRNAs miks are noncoding RNA molecules regulating diverse cellular processes essential in carcinogenesis. Little is known regarding miRs in head and neck squamous cell cancer, expecially in relatin to the chinicopathological fratures of site-specific tumors.
The study comprised of 51 patients with HNSCC (23 oropharyngeal 24 laryngeal and 4 hypopharyngeal carcinomas), five miRs were estinated (let-7a, miR-21, miR-200c, miR-34a, miR-375). the micro RNA profile seems to play a potential role in the pathobiology of oropharyngeal and laryngeal HNSCC. Up-regulation of miR34a in p16-positive oropharyngeal cancer has not been so far descrbed and additional studies are warranted.