The Influence of Persistent Organic Pollutants on Mitochondrial Functions and Origin of Metabolic Syndrome
2015
Abstract
Persistent organic pollutants are bioaccumulative and toxic to living organisms. Persistent substances may increase oxidative stress and start inflammatory processes, which are the major factors in the pathogenesis of obesity-related diseases.
A clear link was found between mitochondrial dysfunction and the type 2 diabetes mellitus. A mutation in mitochondrial DNA beta-cells of pankreas leads to the worsening of insulin secretion, cell apoptosis and subsequent reduction of beta-cells.