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Reprogramming of B cell acute lymphoblastic leukemia cells: Do we need to shoot a moving target?

Publikace na 2. lékařská fakulta |
2015

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

In a recent paper, McClellan et al. report that blasts from some precursor B cell acute lymphoblastic leukemia (B-ALL) cases transdifferentiate (reprogram) into nonmalignant cells. Although showing induced reprogramming in both Philadelphia chromosome-positive (Ph+) and PhMINUS SIGN cases, the authors concentrate on Ph+ leukemias, proposing reprogramming to be a possible therapeutic modality for this high-risk group of B-ALLs.

Although the findings are highly interesting and relevant, we would like to raise several points of concern.

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