Abstract
The quality of the therapy of hypertension significantly affects cardiovascular morbidity and mortality. Effective drug therapy does mean to attain the target blood pressure.
In addition, the rational therapy does mean to achieve a decline in the clinical indicators, i.e. reduction of cardiovascular events. In addition, optimal therapy respects the quality of the patient's lifestyle.
One of the main causes of suboptimal control of hypertension is low compliance and adherence of patients to medication due to inadequate quality of provided therapy. Fixed combinations of antihypertensive drugs represent promising therapeutic strategy, which increases the comfort of the therapy and affects positively compliance and adherence.
Treatment with fixed combinations is also burdened with some disadvantages that pose potential risks for a particular group of patients and may impair the optimal quality of this therapy. The individual decision making between fixed-dose or free-dose combination antihypertensives should be carried out with regard to the presence of other diseases and to the biological status of the patient.