Abstract
Patients and Method: In total of 75 patients, the levels of Bid and Bad were assessed using SDS-PAGE and Western blotting with specific antibodies, with the aim to analyse amount of Bid and Bad proteins in normal (NE), hyperplastic (HE) and cancerous (CE) endometrium. Results: Bid level in CE reached only 47 % and 50 % of this observed in NE and HE.
Conversely, Bad level in HE reached only 40 % and 36 % of this observed in NE and CE, respectively. Conclusion: Trends of Bid and Bad protein levels are obviously opposite in HE and CE.
We suggest that cells in HE maintain sufficient apoptotic program. On the contrary, cancerous cells (CE) show decreased level of direct apoptotic trigger protein Bid and impaired apoptosis and endometrium affected with adenocarcin