Publication at First Faculty of Medicine |
2015
Abstract
Patients vary in their response to medicines. The variation between individuals partly arises due to the variability in drug metabolism enzymes, partly due to the variability in pharmacodynamics, and partly due to non-genetic factors.
This review summarizes inherited differences in drug metabolism which can affect individual responses to drug, both in terms of therapeutic effect as well as adverse effects. The importance of the polymorphisms in phase I- and phase II of drug metabolism is highlighted.
Recent recommendations for testing of some genes involved in drug metabolism are also described.