Experimental determination of diagnostic window of cardiac troponins in the development of chronic anthracycline cardiotoxicity and estimation of its predictive value
2015
Abstract
To the best of our knowledge, this is the first study to precisely describe the diagnostic window and predictive value of cTns in anthracycline cardiotoxicity. Unlike AMI in cardiotoxicity, cTn elevations may be better associated with cumulative dose and concentration steady state than c(max).
While only a mild non-significant increase in both cTn levels occurred after the 1st daunorubicin dose, a significant rise was observed after the 5th and 8th administrations 2 hrs after these administrations, a significant increase occurred with a peak between 4-6 hrs and a decline until 24 hrs.