Abstract
Obesity used to be difficult to treat since most patients exhibited poor long-term adherence to the required diet. It also used to be true that achieving weight reduction in diabetics or in patients with family history positive for diabetes was less likely.
Nowadays, the situation is much better - there is a wide range of possibilities to reduce weight in diabetics, especially using incretin analogues and gliflozins. In Europe, more effective pharmacotherapy of obesity in non-diabetics is missing compared to the U.S.
However, the time is approaching when it will be possible to treat even non-diabetics by incretin analogues and centrally acting anorectics. Despite the effectiveness of modern pharmacotherapy, we must not forget about psychotherapy, lifestyle modifications, and bariatric surgery.
The principles of obesity treatment shall widen even more in future, including so called biological therapy.