Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary disease of the kidney. ADPKD patients form about 6-10% pacients on dialysis.
No clear recommendations about diagnostic possibilities and treatment of ADPKD have been published until now. These recommendations formed large Spanish group focused on hereditary renal diseases.
They are based on the study of current literature about APDKD and on the conclusions of large discussions. All recommendations are only of low level C or D according to Evidence centre based Medicine University of Oxford.
First diagnostic and therapeutical recommendations for ADPKD prepared by Spanish group were published in Nephrology Dialysis Transplantation in September 2014. Studies of Cochran library, MEDLINE and Database of systematic summaries (until December 2013) were included.
The recommendations contain imaging and genetic diagnostic methods, therapy of hypertension and other renal and extrarenal complications. Moreover the recommendations in chronic renal insufficiency and renal replacement therapy in ADPKD and ADPKD children are mentioned.