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Biomechanical response of scaffold on mechanical loading

Publikace na Fakulta tělesné výchovy a sportu |
2015

Tento text není v aktuálním jazyce dostupný. Zobrazuje se verze "en".Abstrakt

Many authors encounter problems associated with insufficient mechanical properties, as the formed tissue is actually not strong enough/resistant, or even earlier, when the cells are not forming optimally or do not grow adequately. This is caused by number of factors, such as suboptimal chemical - biological properties of the scaffold as well as its mechanical properties.

While electrospinning the nanofibers, many parameters can be adjusted, affecting the final properties of the nanofibers (manufacturing solution viscosity, voltage, collector type ....) The properties of the scaffolds are also adjusted by the post-production processes, such as. cross-linking ect. It is evident from the available literature, that there is not a linear dependence on the properties of the nanofibres and the complex nanofibrous structure.

These are characterized by their rheological inhomogenity and the available approaches used to study deformations omit detailed structural changes inside the material. The aim of this work is the detection of mechanical properties through basic viscous, plastic and elastic components with a clear physical interpretation, and effects of hydration on the properties of the scaffolds.