Abstract
Gonadotroph adenomas originate from the gonadotrph cells of the pituitary. The majority of gonadotroph adenomas secrete hormones inefficiently or in low concentrations without clinical manifestation.
Clinically nonfunctioning gonadotropinomas account 80-90% of all nonfunctioning pituitary adenomas. Nonfunctioning gonadotropinomas are mostly recognized as macroadenoma which manifest by unspecified signs of the mass effect.
There is a low percentage of gonadotropinomas which manifest by specific symptoms such as menstrual irregularity and ovarian hyperstimulation syndrome in cases of women, testicular enlargement and an increased sperm count in cases of men, and isosexual precious puberty in cases children. Neurosurgery is the treatment of choice for nonfunctioning gonadotroph adenomas and functioning gonadotroph adenomas.
With regard to the risk of adenoma recurrence the long- term follow- up is similar to that of cases of other pituitary adenomas necessary.