Publication at Faculty of Medicine in Pilsen |
2016
Abstract
Cajal-like interstitial cells (IC-LC) can be detected e.g. in the bladder wall tissue. The current research proves their important role in both physiological and pathological function of this organ.
The authors developed relative simple mathematical model consisting of five nonlinear ODEs. The model accuracy was verified using published experimental results.
Presented nonlinear dynamical system was then analyzed using software MATCONT. This analysis allowed to simulate the effects of various drugs on the function of the bladder.
The drug effects were compared with the experimental results.