Additional treatment with 2-Chloro-2-Deoxyadenosine during consolidation in children with high-risk acute myeloid leukemia does not improve survival

Abstrakt

The outcome in children and adolescents with high-risk (HR) acute myeloid leukemia (AML) is still unsatisfactory. Increasing the intensity of chemotherapy in these patients is difficult because toxicity has already reached a limiting level.

Klíčová slova

• phase-iii
• 2-chlorodeoxyadenosine
• daunorubicin
• induction
• multicenter
• cytarabine
• cladribine
• remission
• analogs