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Magnetic resonance imaging of the brain in patients with normotensive and hypertensive glaucoma

Publication at Faculty of Medicine in Hradec Králové |
2015

Abstract

Objective: The aim of the study was to determine whether there is a correlation between changes in visual fields and degenerative changes in the brain of patients with hypertensive (HTG) and normotensive glaucoma (NTG) and whether these findings differ in both diagnostic groups. Patients and methods of examination: The patient cohort comprised a total of three groups.

The HTG group consisted of 5 women and 6 men (40-73 years) with the average age of 60.7 years. The second - NTG - group consisted of 11 women and 6 men (45-79 years) with the average age of 63.1 years.

The Control group consisted of 9 women and 2 men (56-71) with the average age of 61.7 years. We conducted the visual field examination for all patients, using the Medmont M700 (manufactured by Medmont International Pty Ltd, Australia) fast threshold glaucoma program.

We evaluated the pattern defect (PD). MRI examination included T2 TSE axial sequences.

We quantified the amount of cerebral white matter T2 hyperintense lesions using the Fazekas scale and determined total cerebral atrophy by measurements of the bicaudate ratio. Conclusion: MR brain imaging revealed progression of the degenerative process as assessed by the bicaudate ratio, associated with disease advancement.

Scoring [SYLWAN., 159(11)]. ISI Indexed 29 according to the Fazekas scale exposed lesions in the superficial as well as deep layers of white matter in both NTG and HTG.