Varsseveld, N., C., Bisschop, P., H., L., T., Biermasz, N., R., Pereira, A.,P., Fliers, E., Drent, M.: A long-term follow-up study of eighteen patients with thyrotropin-secreting pituitary adenomas
2015
Abstract
TSH-secreting pituitary adenomas (TSH-omas) are a rare cause of thyrotoxicosis. First-line therapy for these tumours is neurosurgery, although medical therapy with somatostatin analogues (SSAs) is increasingly used for this indication.
Our results demonstrate that patients with TSH-omas, who often present with large macroadenomas with extrasellar extension, have an excellent response to SSA therapy. Because the results of surgery and radiotherapy are disappointing, primary medical therapy may be considered in virtually all patients, except in case of optic chiasm compression, especially in those harbouring large adenomas with parasellar extension.