Publikace na 1. lékařská fakulta |
2015
Abstrakt
Ovarian cancer is the most deadly gynecological cancer. High mortality of the patients is usually associated with the progression of the disease.
Most of the patients are diagnosed within the advanced stages due to lacking relevant diagnostic and screening markers. Achieving the diagnosis in the early stages of disease is a prerequisite of the more successful treatment of ovarian cancer.
In this review, we focus on the recent progress in research focused on circulating, particularly cell-free microRNAs expression in diagnostically relevant samples such as blood, plasma/serum and urine. More research will be needed to establish circulating and extracellular microRNAs as the novel diagnostic markers for ovarian cancer.