Publication at Faculty of Medicine in Pilsen |
2016
Abstract
Castleman disease is rare diagnosis. It was first mentioned in literature in 1954 by doctor Castleman and Lown.
It is rare sickness which primary affects lymfatic nodes. There are four histo-morfologic subtypes and two clinic manifestations (uni and multicentric).
Comon clinical picture is simple lymfadenopathy of neck, medistinal a retroperitonal lymfatic nodes. Signs of this disease are heterogenic and depend on histological subtype.
Also prognosis depends on type of illness. It should take place as benign diagnosis (unicentric form) but also can be potencionally malignant form which should exacerbate to malignant lymfoproliferation (multicentric form).