Abstract
Introduction: Recurrent hemartros in patients with haemophilia leads to inducement of chemical processes that take place in the synovial layer of the joint capsule and articular cartilage, which ultimately lead to the destruction of the articular surfaces and the emergence of haemophilic arthropathy. Growth factors play a key role in the regulation and stimulation of the healing processes and in the regeneration of different tissues.
Applying platelet rich plasma into the affected joint chronic synovialitis, we can expect that there will be reduction of the inflammatory symptoms. Methods and material: We treated a total of 8 hocks in 6 patients with severe haemophilia type A at the age of 9-45 years, mean age was 22 years.
The status of the joints was assessed using magnetic resonance imaging or ultrasound before treatment with growth factors and then 2 months after treatment and at the same intervals, patients were classified using HJHS and VAS scores. Results: Before treatment, all patients had relatively high HJHS (3-12, 6.75 average) and VAS scores (2-4, 2.85 average).
Two months after application of platelet-rich plasma HJHS decreased to 0-10 (mean 4.85). All patients reported pain relief.
This was proved by a decrease in VAS score values that were after treatment 0-2 (average 0.75). The result of examination by imaging methods were 3 cases of regression findings in 5 cases remained unchanged findings.
Discussion: The positive effect of treatment with platelet rich plasma as described in the literature is indisputable, but studies showing the effect of such treatment in haemophiliacs are still lacking. Some studies have shown a good effect in the treatment of PRP joint degeneration in comparison with the established standard treatments.
Generally speaking, patients with osteoarthritis of the effect of treatment with PRP higher in the case of younger patients and degree of disability is less cartilage.