Cyclo 3 Fort fixed combination in the treatment of chronic venous insufficiency Venoactive drugs are a popular group of drugs which have been mostly used in the treatment of chronic venous insufficiency, along with other therapeutic approaches, especially compressive treatment. The article focuses on a review of available data on the Cyclo 3 Fort formulation, both from preclinical (i.e. especially documentation of the mechanism of action) and clinical point of view.