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Fixed combination metformin, dapagliflozin - the advantages of fixed combinations

Publication at Second Faculty of Medicine |
2015

Abstract

Diabetes mellitus 2. typu je chronické metabolické onemocnění, jehož prevalence v posledních letech trvale roste.Type 2 diabetes mellitus is a chronic metabolic disease, the prevalence in recent years, steadily increasing. Its formation occurs primarily due to the formation of insulin resistance, a reduced sensitivity mainly liver, muscle and fat tissues to the effects of insulin.

Later, it occurs and an absolute lack of insulin in reducing insulin secretion. Long-term Hyperglycemia is then crucial factor in the development of vascular complications of diabetes.

It is known that the risk of these complications is closely tied to the level of long-term compensation. The treatment is trying to prevent the emergence of both microvascular and macrovascular complications.