Nickel(II) complexes of N-CH2CF3 cyclam derivatives as contrast agents for 19F magnetic resonance imaging

Abstrakt

Kinetically inert Ni(II) complexes of N(1),N(8)-bis(2,2,2-trifluoroethyl) cyclams with hydrogen atoms or phosphonic acid groups in the N(4),N(11)-positions show significant (19)F NMR relaxation rate enhancement useful for 19-fluorine MRI imaging.

Klíčová slova

• Cambridge-structural-database
• acid pendant arms
• 1,4,8,11-tetraazacyclotetradecane-1,8-bis(methylphosphonic acid)
• clinical-applications
• cis/trans-isomerism
• metal-complexes
• MRI
• probes
• design
• spectroscopy