Cardiac troponinsTranslational biomarkers in cardiology: Theory and practice of cardiac troponin high-sensitivity assays
Abstract
Cardiac troponins (cTns) are a unique translational biomarker in cardiology whose potential has not been diminished in the new era of high sensitive assays. cTns can be valuable markers in cardiac diseases as well as in infectious diseases and respiratory diseases. Furthermore, the role of cTns is growing in the routine evaluation of cardio-pharmacotoxicity and in determining the efficacy/safety ratio of novel cardioprotective strategies in clinical settings. cTns can detect myocardial injury not only in a wide spectrum of laboratory animals in experimental studies in vivo, but also in isolated heart models or cardiomyocytes in vitro.The crucial issue regarding the cross-species usage of cardiac troponin investigation remains the choice of cardiac troponin testing.
This review summarizes the recent proteomic data on aminoacid sequences of cTnT and cTnI in various species, as well as selected analytical characteristics of human cardiac troponin high sensitivity assays. Our survey could help elaborate the practical guidelines for optimizing the choice of cTns assay in cardiology.