Abstract
This is retrospective study. We performed quantification of gene expression of selected genes and some microRNA from tumour tissue, which was used for the diagnosis.
We demonstrated a predictive value of gene expression of thynidylate synthase in tumour tissue for a therapeutic effect of chemotherapy based on 5-Fluorouracil or Capecitabine. Thanks to the use of efficient therapy predictors, we can distinquish those patients who will profit from chemotherapy from patients where an effect cannot be expected.
Thanks to personified oncology therapy the quality of life of some patients can be improved while reducing the costs of the therapy by avoiding inefficient chemotherapy. Only an early dianosis of gastric cancer can reverse the adverse prognosis of patients with this disease.