Optimized methods for preparation of 6(I)-(omega-sulfanyl-alkylene-sulfanyl)-beta-cyclodextrin derivatives
2016
Abstract
A general high-yielding method for the preparation of monosubstituted beta-cyclodextrin derivatives which have attached a thiol group in position 6 is described. The thiol group is attached through linkers of different lengths and repeating units (ethylene glycol or methylene).
The target compounds were characterized by IR, MS and NMR spectra. A simple method for their complete conversion to the corresponding disulfides as well as a method for the reduction of the disulfides back to the thiols is presented.
Both, thiols and disulfides are derivatives usable for well-defined covalent attachment of cyclodextrin to gold or polydopamine-coated solid surfaces.