A 7-methoxytacrine-4-pyridinealdoxime hybrid as a novel prophylactic agent with reactivation properties in organophosphate intoxication

Abstrakt

Chemical warfare agents constitute an increasing threat to both military and civilian populations. Therefore, effective prophylactic approaches are urgently needed.

Herein, we present a novel hybrid compound which is able not only to keep acetylcholinesterase resistant to organophosphate (OP) inhibitors, but also to serve as an enzyme reactivator in the case of OP intoxication.

Klíčová slova

• acetylcholinesterase reactivators
• cholinesterase-inhibitors
• alzheimers-disease
• nerve agent
• pralidoxime
• tacrine
• ligands
• design