Publication at Second Faculty of Medicine |
2016
Abstract
LIN28B is an RNA-binding protein with an oncofetal expression pattern. High LIN28B expression is crucial during human embryogenesis and is down-regulated in most tissues after birth.1 However, reactivation during oncogenesis is common in a plethora of adult cancers, including leukemia, and was also detected in solid pediatric tumors such as neuroblastoma, Wilms tumor, pediatric hepatoblastoma and hepatocellular carcinoma, germ cell tumors and rhabdoid tumors.2 More recently, we identified high LIN28B expression in a large subgroup of juvenile myelomonocytic leukemia (JMML), an aggressive childhood hematopoietic neoplasm.3