Publication at Faculty of Medicine in Hradec Králové |
2016
Abstract
Multiple sclerosis is a chronic inflammatory demyelinating disease which affect central nervous system. This autoimmune disease manifests itself with various symptoms.
This review explore the principle features of the immunopathology of multiple sclerosis. This include a role of T cells, B cells and cytokine netwoks promoting damage of the tissue.
As the etiology of multiple sclerosis is unknown, available agents modify the disease course. Fundamental appreciation of the immmunopathology of multiple sclerosis leads to a broader understanding to mechanism of the agents, that are mentioned.