Abstract
The integrative models of human physiology connect individual physiological subsystems into a single unit. They are very large (contain thousands of variables) and represent a formalized description of interconnected physiological regulations...
The issue of formalization of physiological systems became part of series international projects (e.g. worldwide program "PHYSIOME", or European program "VIRTUAL PHYSIOLOGICAL HUMAN"). The development of large-scale models of human physiology was facilitated by new generation (i.e. equation-based) simulation environment, especially by Modelica language.
These models can be used to explain the causal relations of the pathogenesis of many diseases; they can be applied in the evaluation of clinical trials as well they can be used in the core of sophisticated medical simulators.