Prognostic significance of microvesel density determined using CD34 and CD105 antibody in rectal cancer patients treated with postoperative adjuvant radiotherapy
Abstract
Background: The aim of the study was to assess the prognostic significance of microvessel density determined using CD34 and CD105 antibody in patients treated with postoperative adjuvant radiotherapy for locally advanced rectal adenocarcinoma. Patients and methods: In total 59 patients with locally advanced rectal cancer were studied retrospectively.
Results: The median of follow-up was 75 months (6.3 years). The median microvessel density determined using CD34 antibody was 104.55 capillaries / mm2.
Five-year overall survival according to the median of microvessel density using CD34 antibody: CD34 104.55 = 57 %, logrank: p = 0.42; HR = 0.75. The median microvessel density assessed using determined using CD105 antibody was 31.4 capillaries / mm2.
Five-year overall survival according to the median of microvessel density using CD105 antibody: CD105 31.4 = 56 %, logrank: p = 0.56; HR = 0.82.Conclusion: The results of this study demonstrate microvessel density in locally advanced rectal adenocarcinoma. This study did not show predictive or prognostic significance of microvessel density determined using CD34 and CD105 antibody, which may be due to the limited number of patients.