Epithelial markers of colorectal carcinogenesis in ulcerative colitis and primary sclerosing cholangitis
2013
Abstrakt
Our study shows that the nondysplatic mucosa of UC patients with PSC is characterised by a higher expression of the tumour suppressor gene p53, suggesting a higher susceptibility of cancer. This p53 overexpression correlates with the presence of PSC whilst it is not present in patients with UC after liver transplantation for PSC.