A new hitherto unreported histopathologic manifestation of mammary analogue secretory carcinoma: "masked MASC" associated with low-grade mucinous adenocarcinoma and low-grade in situ carcinoma components
Abstract
We present a salivary gland tumor of the parotid gland in a 54-year-old woman, which contained a minor mammary analogu secretory carcinoma (MASC) component (20%) intermixed with a morphologically entirely different mucinous adenocarcinomatous component that comprised 80% of the tumor mass and a morphologically nondescript low-grade intraductal carcinoma (in situ) component. On fluorescence in situ hybridization, a break in the ETV6 gene was documented in the mucinous adenocarcinomatous, the conventional MASC, and the intraductal (in situ) components.
RT-PCR failed to reveal an ETV6-NTRK3 fusion. The entire conventional MASC and only rare mucinous adenocarcinoma tumor cells were mammaglobin positive, whereas the low-grade intraductal carcinoma (in-situ) component was negative.
S-100 protein stained only the MASC component.