New Synthetic Pyrazine Carboxamide Derivatives as Potential Elicitors in Production of Secondary Metabolite in In vitro Cultures
2016
Abstract
The effect of new synthetic pyrazine carboxamide derivatives on flavonolignan and flavonoid production in Silybum marianum and Fagopyrum esculentum callus and suspension cultures was studied. Compound N-(4-chlorobenzyl)-5-tert-butylpyrazine-2-carboxamide shows to be suitable elicitor for enhanced production of taxifolin and silychristin in S. marianum, mainly when 3.292 x 10-4 mol/L concentration was used and compound 3-(3-((trifluoromethyl)benzyl)amino) pyrazine-2-carboxamide is suitable for increase rutin production in F. esculentum callus cultures.