Publication at First Faculty of Medicine, Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové |
2016
Abstract
Transition metals iron and copper release participates in the myocardial injury under ischemic conditions and hence protection might be achieved by chelators. In this study we tested copper chelator D-penicillamine both in vitro and in vivo.
In vitro on H9c2 cells, the protection against the catecholamine-induced viability loss was observed in a dose-dependent manner. In animals, both intravenous D-penicillamine doses of 11 (low) and 44 mg/kg (high) decreased the mortality caused by s.c. isoprenaline (100 mg/kg) from 36% to 14% and 22%, respectively.
In conclusion, D-penicillamine seem to act as protective compound against catecholamine-induced cardiotoxicity.