Abstract
The serotonergic hallucinogen psilocybin has received a lot of attention due to its potential use in clinical as well as experimental psychiatry, addictology and neurology. This text presents the results of recent clinical studies with psilocybin in the context of its historical use and summarizes the psychological and biological aspects of its effect in specific therapeutic indications.
In addition it discusses the association between its psychotomimetic and therapeutic effects within the framework of the "entropic brain" theory.