Diabetic cardiomyopathy: pathophysiological mechanisms of structural and functional changes

Abstract

Diabetic cardiomyopathy is characterized by significant changes in function and structure of the heart. They have been studied in numerous diabetic experimental models in animals, mostly rodents.

Revealing of potential underlying mechanisms of these pathophysiological alterations holds the promise to design new pharmacological strategies for diabetic patients. Our current review provides an update on functional and structural alterations in the diabetic heart and pathophysiological mechanisms of their development and progression.

Keywords

• cardiomyopathy
• diabetes
• animal models
• diastolic dysfunction
• systolic dysfunction
• pathophysiological mechanisms